Scientific Background

More than 10% of the human proteome contains PRM-binding domains – a class of protein-domains specialized in the recognition of proline-rich motifs.

These domains are involved in a multitude of pathologies, such as cancer, Alzheimer’s and other neurodegenerative diseases, cardiovascular diseases, immune-meditated disorders, etc.

However, they are so far considered as “undruggable”, making peptidomimetic and small molecule competitors of PRM urgently needed.

Scientist close up examining protein molecules
PROSION ProM Platform illustration

PROSION’s ProM Platform

Trough a unique design concept, PROSION established a platform of synthetic Proline-derived modules (ProMs) as the world’s first validated and patented PRM-structure mimicking scaffolds. As stereo-defined building blocks, these can be assembled into urgently needed competitors of PRM. 

Based on this disruptive technology, PROSION is able to develop first-in-class small molecule drugs, for a particularly abundant class of undruggables – finally making PRM binding domains druggable.

Generating ProM-based compounds for drug development

We are striving to push our own drug compounds through pre-clinical and clinical development. The first candidate that we are developing is a highly selective ProM-based inhibitor for Ena/VASP; addressing breast and pancreatic cancer metastasis.

While Ena/VASP is the first POC, the platform has the potential to address various targets and indications.If you are interested in becoming part of this exciting journey, please head to our contact page.
Scientists collaborating for a project
Girl scientist examining protein molecule in a lab

Providing ready-to-use ProMs as lead compounds

ProMs are the first reported and patented mimetics of a very abundant secondary structure of our organism and have thus a vast use-potential in a multitude of areas next to drug discovery (e.g. PROTACs, Biotools, etc.).

We therefore offer a broad range of ProMs, enabling our potential partners to gain an in-depth scientific understanding.

If you are interested in working with our ProMs, please head to our contact page.

Publications

Proceedings of the National Academy of Sciences of the United States of America

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

Angewandte Chemie - International Edition

Triple‐Helix‐Stabilizing Effects in Collagen Model Peptides Containing PPII‐Helix‐Preorganized Diproline Modules

European Journal of Organic Chemistry

Design and Synthesis of Building Blocks for PPII‐Helix Secondary‐Structure Mimetics: A Stereoselective Entry to 4‐Substituted 5‐Vinylprolines

Proceedings of the National Academy of Sciences of the United States of America

A modular toolkit to inhibit proline-rich motif–mediated protein–protein interactions

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